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Representative nBR and PREP curves before an after smoking in a single subjects. NBR and PREP before smoking is shown in black. NBR and PREP after smoking is shown in red. (A) Area under the curve is decreased after smoking a cigarette suggesting an inhibition of trigeminal pain processing at brainstem level. (B) N2 and P2 latency are reduced after smoking a cigarette suggesting a facilitation of trigeminal pain processing at supraspinal level.
