TABLE 2.
Ampicillin as prescribed by primary physician
| Group | n | Daily dose (mg/kg/day)a | Amt per dose (mg/kg)a | Dosing interval | Typical POPSb dose |
|---|---|---|---|---|---|
| 1 | 21 | 200 (161–303) | 100 (81–109) | 19% every 8 h, 81% every 12 h | 100 mg/kg every 12 h |
| 2 | 7 | 185 (113–194) | 93 (57–97) | 100% every 12 h | 100 mg/kg every 12 h |
| 3 | 27 | 218 (100–307) | 100 (43–102) | 59% every 8 h, 41% every 12 h | 75 mg/kg every q 8 h |
| 4 | 18 | 282 (184–350) | 92 (46–100) | 44% every 6 h, 28% every 8 h, 28% every 12 h | 100 mg/kg every 8 h |
| Overall | 73 | 200 (100–350) | 98 (43–109) | 11% every 6 h, 34% every 8 h, 55% every 12 h | 100 mg/kg every 12 h |
a
Numbers represent median (range).
b
POPS, NIH-funded study supporting this work that focuses on pharmacokinetics of understudied drugs administered to children per standard of care.