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. 2014 Jun;58(6):3013–3020. doi: 10.1128/AAC.02374-13

TABLE 3.

Ampicillin model-building processa

Model Population model Objective function value Change in objective function from base model
V (base model) V = θV · WTKG 1,284
CL (base model) CL = θCL · WTKG 1,284
Birth wt CL = θCL · WTKG · (BW/2,500)θ(2),BW 1,284 0
DOL CL = θCL · WTKG · (DOL/7)θ(2),DOL 1,278 −6.108
GA CL = θCL · WTKG · (GA/36)θ(2).GA 1,257 −26.81
PMA CL = θCL · WTKG · (PMA/37)θ(2),PMA 1,251 −33.34
SCR CL = θCL · WTKG · (0.6/SCR)θ(2),SCR 1,249 −34.85
SCR, PMA (final) CL = θCL · WTKG · (0.6/SCR)θ(2),SCR · (PMA/37)θ(2),PMA 1,229 −55.19
a

V, volume; WTKG, = weight in kg; CL, clearance; BW, birth weight; DOL, days of life (defined as postnatal age + 1 day); GA, gestational age; PMA, postmenstrual age; SCR, serum creatinine.