TABLE 3.
Model | Population model | Objective function value | Change in objective function from base model |
---|---|---|---|
V (base model) | V = θV · WTKG | 1,284 | |
CL (base model) | CL = θCL · WTKG | 1,284 | |
Birth wt | CL = θCL · WTKG · (BW/2,500)θ(2),BW | 1,284 | 0 |
DOL | CL = θCL · WTKG · (DOL/7)θ(2),DOL | 1,278 | −6.108 |
GA | CL = θCL · WTKG · (GA/36)θ(2).GA | 1,257 | −26.81 |
PMA | CL = θCL · WTKG · (PMA/37)θ(2),PMA | 1,251 | −33.34 |
SCR | CL = θCL · WTKG · (0.6/SCR)θ(2),SCR | 1,249 | −34.85 |
SCR, PMA (final) | CL = θCL · WTKG · (0.6/SCR)θ(2),SCR · (PMA/37)θ(2),PMA | 1,229 | −55.19 |
V, volume; WTKG, = weight in kg; CL, clearance; BW, birth weight; DOL, days of life (defined as postnatal age + 1 day); GA, gestational age; PMA, postmenstrual age; SCR, serum creatinine.