TABLE 5.
Individual empirical Bayesian post hoc parameter estimatesa
| Group | n | Clearance (liters/h/kg) | Volume (liters/kg) | Half-life (h) | Steady-state concn (μg/ml) |
|
|---|---|---|---|---|---|---|
| Minimum | Maximum | |||||
| 1 | 21 | 0.055 (0.03–0.07) | 0.40 (0.40–0.40) | 5.0 (3.9–9.4) | 77 (36–320) | 318 (244–563) |
| 2 | 7 | 0.070 (0.03–0.07) | 0.40 (0.40–0.41) | 4.0 (3.8–8.3) | 33 (21–145) | 266 (159–368) |
| 3 | 27 | 0.086 (0.04–0.13) | 0.40 (0.40–0.40) | 3.2 (2.2–6.2) | 48 (5–173) | 274 (127–413) |
| 4 | 18 | 0.11 (0.06–0.13) | 0.40 (0.40–0.41) | 2.4 (2.1–4.7) | 28 (5–129) | 246 (138–203) |
| Overall | 73 | 0.072 (0.03–0.13) | 0.40 (0.40–0.41) | 3.3 (2.1–9.4) | 47 (5–320) | 281 (127–563) |
a
All values are medians and ranges.