FIG 1.

Therapeutic efficacies of oral ciprofloxacin and intranasal CFI against an inhalational F. tularensis LVS infection in mice. Groups of 5 BALB/c mice were challenged with F. tularensis LVS via the intranasal (I/N) route and treated at 72 h (solid lines) or 96 h (dotted lines) postchallenge with a single 50-mg/kg dose of oral ciprofloxacin (diamonds), intranasal CFI (circles), or PBS (squares) delivered by the intranasal route. (A) Survival of mice. Only mice treated with PBS succumbed to the infection. (B) Clinical scores of mice. Mice were scored on the extent of piloerection, hunching, eye problems, and locomotion, with scores of 0, 1, and 2 specified for each category. (C) Weight change of mice over the course of the experiment. There were no significant differences in weight between mice dosed with oral ciprofloxacin or intranasally instilled CFI.