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Pharmacokinetic parameters of ciprofloxacin in lung homogenate following a single dose of oral ciprofloxacin, intranasal CFI, or aerosolized CFI
| Therapy | Dose (mg/kg) | Cmax (μg/g) | t1/2 (h) | Clearance (kg/h/kg) | AUC0–24 (h · μg/g) |
|---|---|---|---|---|---|
| Oral ciprofloxacin | 50 | 55.8 | 4.2 | 5,014.7 | 9.2 |
| Intranasal CFI | 50 | 3,326.7 | 6.6 | 0.8 | 52,373.8 |
| Aerosolized CFI | 1a | 116.1 | 7.4 | 1.2 | 772.7 |
Actual received lung dose (determined during pharmacokinetics study from 1-min time point).
