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Differential mechanisms of RdRp inhibition by the four NIC compounds. In order to determine the mode of inhibition, RdRp activity was measured at different concentrations of substrate (0.2 to 66 μM) in the presence of 0 to 20 μM inhibitors. Double-reciprocal plots were generated for NIC02 (A), NIC04 (B), NIC10 (C), and NIC12 (D). RFU, relative fluorescence units.
