TABLE 3.

Patients with non-IgE-mediated HSRs to nafcillin switched to cefazolin^a

Patient no.	Age (yr)/gender	Infectious diagnosis	Pathogen	HSR	Duration of therapy prior to HSR onset (days)	Level of care required for HSR management	Therapy outcome
1	40/F	Prosthetic joint infection	MSSA	Maculopapular rash	9	Hospitalization	Completed cefazolin
2	25/M	Epidural abscess	MSSA	Maculopapular rash	22	Hospitalization	Completed cefazolin
3	50/M	Epidural abscess	MSSA	Maculopapular rash	26	Office visit	Completed cefazolin
4	50/F	Septic arthritis	Group A streptococcus	Maculopapular rash	8	Hospitalization	Completed cefazolin
5	80/F	Hardware infection	MSSA	Maculopapular rash	13	Office visit	Completed cefazolin
6	41/M	Septic arthritis	MSSA	Maculopapular rash	24	Hospitalization	Completed cefazolin
7	69/F	Endocarditis	CoNS	Maculopapular rash	9	Office visit	Completed cefazolin
8	64/F	Osteomyelitis	MSSA	Maculopapular rash	21	Office visit	Completed cefazolin
9	26/M	Osteomyelitis	MSSA	Maculopapular rash	9	Hospitalization	Completed vancomycin
10	25/M	Osteomyelitis	CoNS	Maculopapular rash	7	ED visit	Completed cefazolin
11	72/M	Endocarditis	MSSA	Immune-mediated nephritis	19	Hospitalization	Completed cefazolin
12	48/F	Septic thrombophlebitis	MSSA	Immune-mediated nephritis	13	Hospitalization	Completed cefazolin
13	73/M	Hardware infection	MSSA	Immune-mediated nephritis	15	ED visit	Completed cefazolin
14	54/M	Bacteremia	MSSA	Eosinophilia	20	Hospitalization	Completed cefazolin
15	82/F	Osteomyelitis	MSSA	Eosinophilia	36	Office visit	Completed cefazolin
16	79/F	Hardware infection	MSSA	Serum sickness	19	SNF visit	Completed cefazolin
17	74/F	Osteomyelitis	MSSA	Immune-mediated hepatitis	20	Hospitalization	Completed cefazolin

^aData are for 17 patients. Abbreviations: M, male; F, female; MSSA, methicillin-sensitive Staphylococcus aureus; CoNS, coagulase-negative Staphylococcus; ED, emergency department; SNF, skilled nursing facility.