TABLE 1.

Killing activity of DOR, GENT, and COL alone or in combinations against 14 GENT-susceptible KPC-K. pneumoniae clinical strains

Strain	MIC (μg/ml) of:			ompK36 genotype	Killing activity (log10 CFU/ml)a of:
	DOR	GENT	COL		DOR	GENT (10 μg/ml)	GENT (2 μg/ml)	COL	DOR+COL	DOR+GENTb	GENT+COL	DOR+GENT+COL
216	4	0.5	8	WTc	3.71	−6.08	1.19	3.91	0.72	−6.09	−6.11	−6.11
347	8	2	0.25	WT	3.90	−6.03	−3.95	2.07	−4.57	−6.06	−3.74	−6.09
709	8	0.5	0.5	WT	4.06	−5.90	−5.88	−5.86	−5.87	−5.92	−5.92	−5.89
539	32	2	1	ins 382G	3.71	−6.02	1.02	−1.00	−6.08	2.10	−6.13	−6.10
41	2	1	0.25	del 84-87NNTE	3.68	−6.05	−4.79	3.60	−6.03	−6.02	−6.05	−6.03
115	32	0.5	0.125	ins aa134-135GD	3.93	−6.04	−6.14	3.75	3.65	−6.14	−6.15	−6.16
743	64	0.5	0.25	ins aa134-135GD	4.25	−5.71	1.73	1.73	−2.81	−3.86	−5.77	−5.75
155	32	1	0.25	ins aa134-135GD	3.70	−6.08	−6.08	1.68	2.77	−6.10	−6.05	−6.09
484	128	1	0.25	ins aa134-135GD	3.95	−6.02	−4.03	1.48	2.15	−4.08	−6.02	−6.02
807	64	0.5	0.5	ins aa134-135GD	3.93	−6.01	−6.05	3.89	3.83	−6.10	−6.05	−6.06
615	128	2	0.5	ins aa134-135GD	3.86	−6.06	3.92	3.93	3.87	3.69	−2.62	−0.68
436	32	2	0.5	ins aa134-135GD	3.82	−6.08	−6.11	3.79	3.78	−6.11	−6.09	−6.10
669	64	1	4	ins aa134-135GD	3.75	−6.08	−2.01	1.09	−0.08	−1.68	−6.08	−6.05
184	32	0.5	8	ins aa134-135GD	3.83	−6.08	−6.12	3.96	3.80	−6.11	−6.09	−6.13

^aKilling activity was defined as the difference between the log₁₀ concentration of KPC-K. pneumoniae after 24 h of incubation with drug(s) and the log₁₀ of starting inoculum. Positive numbers denote growth of strains compared with starting inoculum.

^bGentamicin concentration was 2 μg/ml during combination testing.

^cWT, wild type.