TABLE 1.
Caspofungin and voriconazole concentrations in cerebrospinal fluid and serum at different time points
| Parametera | Day 1 | Day 5 | Day 11 | Day 17b | Day 18b |
|---|---|---|---|---|---|
| CSF parameter | |||||
| WBC/μl | 790 | 680 | 400 | 370 | 70 |
| PMN (%) | 80 | 80 | 75 | 60 | 60 |
| Protein level (g/liter) | 2.07 | 1.74 | 2.3 | 2.1 | 1.75 |
| Glucose level (mmol/liter) | 5.2 | 3.0 | 3.2 | 1.6 | |
| Serum caspofungin concn (mg/liter) | |||||
| Trough | 10 | 18.5 | 16.2 | 8.2 | |
| 2 h and 8 h after administration | 30.7 and 17.6 | ||||
| CSF caspofungin concn (mg/liter) | |||||
| Trough | 8 | 3.5 | 1 | 1 | |
| 2 h and 8 h after administration | 1.1 and 1 | ||||
| Serum voriconazole concn (mg/liter) | |||||
| Trough | 8.5 | 5.2 | 2.3 | ||
| 2 h and 8 h after administration | 4 and 2.9 | ||||
| CSF voriconazole concn (mg/liter) | |||||
| Trough | 3.7 | 3.4 | 0.9 | 1 | |
| 2 h and 8 h after administration | 1 and 1.1 |
a
CSF, cerebrospinal fluid; WBC, white blood cells; PMN, polymorphonuclear cells.
b
On days 17 and 18, CSF samples were obtained from ventricular drainage.