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. 2014 Jun;58(6):3485–3495. doi: 10.1128/AAC.02495-13

TABLE 5.

Transient replication assays of BMS-791325 resistance-associated NS5B variants selected in vitro

Variant	Genotype 1a			Genotype 1b
Variant	EC₅₀ (nM)^a	Fold change^b	Replication efficiency^b	EC₅₀ (nM)^a	Fold change^b	Replication efficiency^b
Wild type	5.0 ± 0.6		1.0	8 ± 0.5		1.0
P495A	59 ± 5	12	0.7	115 ± 29	14	0.4
P495S	336 ± 36	67	0.2	350 ± 57	44	0.1
P495L	154 ± 25	31	0.3	290 ± 111	36	0.1
P495T	293 ± 124	59	0.1
L392I^c		5–7	0.1–0.4

^a

Mean ± standard deviation from two or more independent experiments.

^b

Versus wild type.

^c

Data from work of Pelosi et al. (38).