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BMS-791325 activity against drug-resistant genotype 1b replicons
| Protein | Mutation | BMS-791325 EC50 (nM)a | Fold change (vs wild-type Con1) |
|---|---|---|---|
| NS5B polymerase | Wild-type Con1 | 5.0 ± 1.0 | |
| S282T | 4.0 ± 1.4 | 0.8 | |
| L392I | 35 ± 12 | 7 | |
| P495S | 192 ± 21 | 38 | |
| M423T | 5.0 ± 1.0 | 1 | |
| M414T | 7.0 ± 3.0 | 1.4 | |
| C316Y | 2.0 ± 1.0 | 0.4 | |
| NS3 protease | R155Q | 5.3 ± 2.2 | 1 |
| A156V | 2.4 ± 0.4 | 0.5 | |
| D168V | 3.0 ± 0.2 | 0.6 | |
| NS5A | Y93H | 3.8 ± 0.9 | 0.8 |
| L31V + Y93H | 2.9 ± 0.6 | 0.6 |
Mean (± standard deviation) from two or more independent experiments.
