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Liver and plasma 24-h concentrations and AUC values of BMS-791325 in nonclinical animal modelsa
| Animal (dose) and pharmacokinetic parameter | Liver | Plasma | Liver/plasma ratio |
|---|---|---|---|
| Rat (10 mg/kg) | |||
| C24 (μM) | 0.63 | 0.05 | 12.2 |
| AUCinf (μM · h) | 645.82 | 42.99 | 15 |
| Dog (3 mg/kg) | |||
| C24 (μM) | 2.13 | 1.33 | 1.6 |
| AUCinf (μM · h) | 152.92 | 78.16 | 2 |
| Monkey (3 mg/kg) | |||
| C24 (μM) | 0.12 | 0.002 | 60 |
| AUC24 (μM · h) | 51.32 | 2.13 | 24.1 |
Values were derived from one animal (dog and monkey) or two animals (rat) per time point.
