TABLE 1.
Population PK parameter estimates of RFP and desRFP
| Parameter | Estimate | % SE |
|---|---|---|
| CL (liters/h) | 1.18 | |
| V (liters) | 41 | |
| ka (h−1) | 2 | |
| MTT (h) | 1.1 | |
| No. of transit compartments | 10 | |
| θdose,F | 0.025 | |
| CLm/Fm (liters · h−1) | 3.1 | 22.3 |
| Vm/Fm (liters) | 15.5 | 18.3 |
| θdose,Fm | 0.049 | 57.6 |
| IIVa (variances plus % CV) | ||
| ƞCL | 0.136 (36.9) | |
| ƞV | 0.0566 (23.8) | |
| ƞMTT | 0.307 (55.4) | |
| ƞCLm | 0.32 (56.6) | 32.2 |
| Covariance for ƞCL∼ ƞV (covariance and correlation) | 0.0684 (0.780) | |
| Residual variability | ||
| Additive error for RFP (mg · liter−1) | 0.48 | 14.4 |
| Proportional error for RFP | 0.26 | 3.0 |
| Additive error for desRFP (mg · liter−1) | 0.072 | 17.8 |
| Proportional error for desRFP | 0.40 | 2.5 |
a
IIV, interindividual variability. Values of IIV are shown in parentheses as % CV; etas represent the random variable with zero mean that distinguishes individual pharmacokinetic parameters from the population mean (the variances of etas are data before the parentheses).