FIG 3.

Replication capacity of NS3 mutant replicons under treatment with various concentrations of DNV. Replicon cells transfected with NS3 mutant constructs were dosed with 0.5% DMSO as a control or DNV, as indicated. Replication capacity was determined as the luciferase signal at 96 h posttransfection divided by that at 4 h posttransfection. The replication capacity of mutant replicons is expressed as a fraction of that of the GT 1a H77 reference replicon, which is set to a value of 1. Error bars represent standard deviations from 3 to 8 experiments. WT, wild type.