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Phylogenetic relatedness among the experimentally tested ARE proteins. The maximum likelihood tree, using YkpA as an outgroup REG protein, was built by PhyML using the best-fitting model, which consists of WAG plus I (0.05) plus G (2.54), and 1,000 bootstraps. The basal group corresponds to ARE proteins from the MLS producers. Three main ARE groups were recovered; they correspond to Lsa proteins, Msr proteins, and Vga proteins. Sal(A) is closer to Lsa than to Vga.
