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Predicted in vivo mycobactericidal activity of U-603 and U-480, individually and in combination, after simulated oral dosing with sutezolid at 600 mg BID and 1,200 mg QD. (Top) Activity at discrete time points; (bottom) cumulative activity, calculated as the integral over time of values at discrete time points. Shading indicates the 90% CI on the basis of PK variability.
