TABLE 1.

Key pharmacokinetic parameters for sealed and unsealed drill holes in cortical bone

Pharmacokinetic parametera	Sealed drill holes (mean ± SEM)	Unsealed drill holes (mean ± SEM)	P
AUC0-last (min · μg/ml)	868 ± 233	1,037 ± 318	0.38
Cmax (μg/ml)	4.8 ± 1.0	5.7 ± 1.4	0.42
Tmax (min)	84 ± 12.7	105 ± 11.8	0.33
T50% of Cmax (min)	31.8 ± 5.8	28.7 ± 4.7	0.61
t1/2 (min)	136 ± 42.0	142.2 ± 59.3	0.93

^aC_max, peak drug concentration in serum; T_max, time to C_max; T_{50% of Cmax}, time to 50% of C_max; t_1/2, half-life at β phase; AUC_0-last, area under the concentration-time curve from 0 to the last measured value.