TABLE 2.
Key pharmacokinetic parameters for plasma, subcutaneous tissue, and cancellous boneb
| Pharmacokinetic parametera | Total plasma | Free plasma | Subcutaneous tissue | Cancellous bone | Pc |
|---|---|---|---|---|---|
| AUC0-last (min · μg/ml) | 8,450 ± 1,911 | 6,227 ± 1,449 | 3,386 ± 1,120d | 2,292 ± 660e | 0.01 |
| Cmax (μg/ml) | 154.4 ± 45.7 | 109.9 ± 31.4 | 24.0 ± 6.5e | 22.9 ± 6.3e | <0.01 |
| Tmax (min) | 30.0 ± 0 | 30.0 ± 0 | 50.0 ± 8.2 | 50.0 ± 0 | |
| t1/2 (min) | 60.8 ± 9.6 | 66.6 ± 11.5 | 85.4 ± 34.9 | 56.4 ± 6.6 | 0.40 |
| T50% of Cmax (min) | 11.0 ± 1.7 | 10.7 ± 2.2 | 16.8 ± 1.4e | 22.5 ± 1.5e | <0.01 |
| fAUCISF tissue/fAUCplasma | 0.58 ± 0.19 | 0.45 ± 0.13 | 0.57f |
a
Cmax, peak drug concentration in serum; Tmax, time to Cmax; t1/2, half-life at β phase; AUC0-last, area under the concentration-time curve from 0 to the last measured value; fAUCISF tissue/fAUCplasma, free area under the concentration-time curve ratio of interstitial fluid (ISF) tissue to free plasma.
b
All values (other than P values) are expressed as the mean ± SEM.
c
One-way ANOVA for free plasma, subcutaneous tissue, and cancellous bone.
d
P < 0.05 for comparison with the corresponding free plasma value.
e
P < 0.01 for comparison with the corresponding free plasma value.
f
By t test.