FIG 1.
Responses of E. cloacae 293HT96 to continuous infusion of ceftazidime combined with two different concentration-time profiles of avibactam in the hollow-fiber model. Shown are results obtained with an untreated growth control (open diamonds), continuous infusion of ceftazidime (8.2 μg/ml) and avibactam (1.6 μg/ml) (open squares), and continuous infusion of ceftazidime (8.2 μg/ml) with a single-dose profile of avibactam (Cmax, 31 μg/ml at 0.5 h) (open circles) and 99.9% bacterial killing (broken line).