. 2014 Jun;58(6):3366–3372. doi: 10.1128/AAC.00080-14

TABLE 2.

Estimates of the avibactam C_T in hollow-fiber experiments

Strain	Ceftazidime		Avibactam		Time (h) when C_T was estimated	Estimated C_T (μg/ml)
Strain	Constant concn (μg/ml)	AUC_0-24h (mg · h · liter⁻¹)	C_max (μg/ml)	AUC_0-24h (mg · h · liter⁻¹)	Time (h) when C_T was estimated	Estimated C_T (μg/ml)
E. cloacae^a 293HT96	8.2	195	31.0	54.7	12	≤0.15^b
K. pneumoniae^a 283CF5	8.3	198	8.9	16.4	12	≤0.22^b
K. pneumoniae^a Tunisie K4	9.4–9.8	232	36.9	63.8	12	≤0.28^b
E. cloacae^c 293HT96	20	480	∼60	126	18–20	∼0.2

Concentrations were estimated at the 12-h sampling time (last sample showing growth suppression [Fig. 1]). Regrowth started at some time between the 12- and 24-h sampling times.

The magnitude of C_T is expressed as less than or equal to the stated value, as estimates were made at 12 h, whereas regrowth occurred between 12 and 24 h (Fig. 1).

C_T was estimated at 18 to 20 h, as the 2-h sampling times allowed greater precision in identifying the time at which regrowth occurred (Fig. 2). However, the declining avibactam concentrations were modeled rather than measured in this experiment (23), and so the estimate of C_T is approximate.