TABLE 3.
Growth suppression windowsa obtained for 24-h ceftazidime infusion with avibactam infused for 24 h or administered once at time zero
| Strain | Constant ceftazidime-avibactam infusionb |
Ceftazidime constant infusion, avibactam single dose at t = 0 hc |
||||
|---|---|---|---|---|---|---|
| Ceftazidime infused (μg/ml) | Avibactam infused (μg/ml) | Growth suppression window (h) | Ceftazidime infused (μg/ml) | Avibactam Cmax (μg/ml) | Growth suppression window (h) | |
| E. cloacae 293HT96 | 8 | 4 | 22 | 8 | 50 | 24 |
| 16 | 4 | 24 | 16 | 60 | 14 | |
| 8 | 4 | 24 | 8 | 20 | 24 | |
| 8 | 2 | 24 | 8 | 30 | 16 | |
| 8 | 2 | 24 | 8 | 30 | 16 | |
| 8 | 2 | 24 | 8 | 30 | 24 | |
| K. pneumoniae 181 | 16 | 4 | 24 | 8 | 60 | 10 |
| K. pneumoniae 236 | 16 | 4 | 24 | 8 | 60 | 24 |
| K. pneumoniae 283CF5 | 16 | 2 | 24 | 16 | 60 | 24 |
| 16 | 4 | 24 | 8 | 60 | 24 | |
| 8 | 2 | 24 | 8 | 30 | 24 | |
| 8 | 1 | 24 | 8 | 12 | 24 | |
| K. pneumoniae 283KB5 | 8 | 4 | 24 | 8 | 20 | 24 |
| 8 | 2 | 24 | 8 | 30 | 24 | |
| 8 | 1 | 24 | 8 | 12 | 24 | |
| Citrobacter freundii 261GR3 | 8 | 4 | 24 | 8 | 20 | 24 |
a
The growth suppression window is the period of time for which the viable count remained at least 103-fold lower than the starting inoculum.
b
Both ceftazidime and avibactam were infused for 24 h at the concentrations listed.
c
Ceftazidime was infused for 24 h at the concentrations listed, and avibactam was administered as a single dose with a t½ of 2 h.