TABLE 1.

Demographics and clinical characteristics of the 146 patients used in this study

Demographic or clinical characteristic	Mean (median) [range] value for the characteristic in the following studya:
	Felton et al.	Boselli et al.	Lodise et al.	Combined	Roberts et al.
Estimated creatinine clearance (ml/min)	115.0 (111.5) [38.0–169.1]	69.8 (52.0) [14.0–245.7]	89.0 (85.5) [27.0–221.0]	85.9 (81.0) [14.0–245.7]	165.5 (163.7) [58.8–256.6]
Wt (kg)	77.0 (71.5) [38.1–122.5]	73.0 (68.5) [49.0–113.0]	70.5 (69.0) [50.0–98.5]	71.7 (69.0) [38.1–122.5]	86.8 (82.5) [72.0–132.0]
Sex (no. of males:no. of females)	8:4	25:15	54:40	87:59	6:2
Age (yr)	46.8 (49.5) [20.0–69.0]	62.3 (64.0) [34.0–88.0]	54.2 (55.0) [18.0–78.0]	55.8 (56.0) [18.0–88.0]	43.6 (41) [19.0–75.0]
No. of patients	12	40	94	146	8
No. of doses	9.58 (9.00) [4.00–24.00]	48-h continuous infusion	1 or 2	N/A	4 or 5
No. of observations per patient	5.9 (6.0) [4.0–8.0]	3.0 (3.0) [3.0–3.0]	6.5 (6.0) [2.0–10.0]	5.5 (6.0) [2.0–10.0]	24 (24) [21–26]

^aThe values for three studies, Felton et al. (6), Boselli et al. (21), and Lodise et al. (20), are shown. The values for the three studies together are shown in the Combined column. The values for the validation cohort of Roberts et al. (27) are shown. N/A, not available.