FIG 3.

Comparison of RT-SHIV dynamics following a HAART (three-drug) or enhanced-HAART (four- or five-drug) regimen in rhesus macaques. Nonparametric analysis was performed on the viral-load data sets from each treatment cohort, assuming nonlinear decay kinetics. The AUC was determined for each individual animal and normalized by subtracting the initial viral load (logV₀) from each subsequent viral load during treatment (logV). (A) Box plots of the median log decrease in the viral load after 1 week of treatment for each cohort (enhanced HAART or HAART). Both enhanced-HAART regimens resulted in significantly greater reduction in the viral load than HAART (P < 0.01). (B) Median AUC of log(V₀/V) versus the time from the start of treatment (time zero) to the point at which two consecutive samples were at undetectable levels (<50 copies/ml). Again, both enhanced-HAART regimens resulted in significant increase in the AUC compared to HAART (P < 0.05).