TABLE 2.
PK parameters estimated for CIP and MXF based on simultaneous analyses of plasma and ELF drug concentrations following i.v. administration or intratracheal administration of nebulized drug
| Parametera (units) | CIP value (CVb [%]) | MXF value (CVb [%]) |
|---|---|---|
| Vc (liters/kg) | 2.39 (36) | 0.844 (38) |
| VP1 (liters/kg) | 2.09 | 1.22 |
| VP2 (liters/kg) | 1.18 | |
| VELF (liters/kg) | 30 × 10−6 (fixed) | 30 × 10−6 (fixed) |
| Faero (%) | 98 | 98 |
| CLT (liters/h/kg) | 3.42 (27) | 1.60 (24) |
| Q1 (liters/h/kg) | 3.56 (9) | 5.71 |
| Q2 (liters/h/kg) | 0.632 (39) | |
| QELF (liters/h/kg) | 0.634 × 10−3 (7) | 6.15 × 10−3 (74) |
| CLout (liters/h/kg) | 0.700 × 10−3 (134) | 57.1 × 10−3 |
| Residual errors | ||
| Plasma | ||
| Additive (μg/ml) | 0.004 | 0.004 |
| Proportional (%) | 12 | 6 |
| ELF | ||
| Proportional (%) | 7 | 12 |
a
Vc, volume of distribution in central compartment; VP1 and VP2, volumes of distribution in peripheral compartments; VELF, fixed volume of distribution in ELF compartment (30 × 10−6 liters/kg); Faero, systemic bioavailability after nebulization; CLT, total systemic clearance; Q1 and Q2, equilibrium distribution clearances between central compartment and peripheral compartments; QELF and CLout, transfer clearances between central compartment and ELF compartment.
b
CV, interindividual variability, expressed as the coefficient of variation.