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Susceptibility of AZ-27-resistant virus to RSV inhibitors. RSV A2 virus was cultured in HEp-2 cells in the presence of DMSO (●; control) or AZ-27 (▲, 0.06 μM; □, 0.3 μM) for 4 weeks. The titers of the surviving viruses were determined, and the viruses were tested in a 3-day RSV ELISA in HEp-2 cells to determine their susceptibility to AZ-27 (A), ribavirin (B), YM-53403 (C), and BI cpd D (D). The data shown are means ± standard deviations of triplicates from a representative experiment.
