FIG 4.

Conservation of RSV L domain conferring resistance to AZ-27. (A) Sequence alignment of the L protein fragments from RSV and other paramyxoviruses overlapping the AZ-27 resistance site Y1631 (circle). Amino acid position numbers of MeV L protein are shown on the top. (B) Conservation of the RSV L protein sequences. One hundred two full-length RSV L protein sequences available were compared to the RSV L consensus sequence. The level of conservation at each amino acid (aa) position for RSV A (blue line) and B (red line) isolates is depicted as the percentage of isolates sharing the consensus sequence. The open boxes on top mark the two variable regions, and the black box highlights the location of the fragment depicted in panel A. The two alignment gaps are labeled with asterisks.