TABLE 3.
AZ-27 activity against RSV infection in different cell types
| Compound | RSV A2 EC50 (μM)c |
||||
|---|---|---|---|---|---|
| HEp-2a | A549a | HEK293a | BHK-21a | HBEC-ALIb | |
| RSV604 | 1.6 ± 0.26 | 1.2 ± 0.14 | 0.77 ± 0.17 | >50 | 0.44 ± 0.30 |
| AZ-27 | 0.01 ± 0.004 | 0.03 ± 0.006 | 0.02 ± 0.003 | 0.05 ± 0.03 | 0.07 ± 0.03 |
a
EC50 measured by RSV ELISA in the indicated cell types following 3-day infection and compound treatment.
b
EC50 measured by qRT-PCR quantitation of viral RNAs in HBEC-ALI following 3-day infection and compound treatment.
c
Data are means ± standard deviations (n = 2 to 5).