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Plasma concentration-time profiles of cationic diamidines following intravenous (filled circles) or oral (open circles) administration to healthy mice. A single dose of pentamidine, DB75, DB820, or DB829 was administered i.v. (7.5 μmol/kg, or approximately 2.3 to 2.6 mg/kg) or p.o. (100 μmol/kg, or approximately 30 mg/kg) to male Swiss Webster mice. Symbols and error bars represent means and standard errors of triplicate determinations.
