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Plasma (filled circles) and brain (open squares) concentration-time profiles of cationic diamidines following intraperitoneal administration to healthy mice. A single dose of pentamidine, DB75, DB820, or DB829 was administered i.p. (65 μmol/kg, or approximately 20 to 22 mg/kg) to male Swiss Webster mice. Symbols and error bars represent means and standard errors of triplicate determinations.
