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. 2014 Jul;58(7):4064–4074. doi: 10.1128/AAC.02605-14

FIG 4.

FIG 4

Drug exposure-effect relationships of cationic diamidines in the T. b. rhodesiense STIB900 acute mouse model. Dotted lines connect data points from pentamidine, DB75, DB820, and DB829, respectively. Relevant in vitro antitrypanosomal activities and in vivo efficacies of cationic diamidines were previously published by Wenzler et al. (6) and are summarized in Table S1 in the supplemental material.