TABLE 1.
The molecular characteristics of different pulsotypes among a global collection of ST131 isolates that produce extended-spectrum β-lactamases
| Pulsotype (n)a | Isolate origin(s) | β-Lactamase(s) (n) | PMQRb determinant(s) (n) | Virotype | fimH lineage | H30-Rx (n) | gyrA allele(s) | parC allele(s) |
|---|---|---|---|---|---|---|---|---|
| A (8) | Canada, New Zealand | CTX-M-15 (8) | aac(6′)-lb-cr (6) | C | H30 | 8 | gyrA1AB | parC1aAB |
| B (20) | Canada, France, South Africa, New Zealand | CTX-M-14 (20) | aac(6′)-lb-cr (2) | C | H30 | 0 | gyrA1AB | parC1aAB |
| C (11) | Canada, India, South Africa | CTX-M-15 (11) | aac(6′)-lb-cr (10) | C | H30 | 11 | gyrA1AB | parC1aAB |
| D (22) | Canada, New Zealand | CTX-M-15 (22) | aac(6′)-lb-cr (22) | C | H30 | 22 | gyrA1AB | parC1aAB |
| E (5) | Canada | CTX-M-14 (2) CTX-M-24 (1) CTX-M-27 (2) | Negc | C | H30 | 0 | gyrA1AB | parC1aAB |
| F (7) | Canada, New Zealand | CTX-M-15 (7) | aac(6′)-lb-cr (4) | C | H30 | 7 | gyrA1AB | parC1aAB |
| G (11) | Canada, United States, South Africa | CTX-M-15 (11) | aac(6′)-lb-cr (8) | C | H30 | 11 | gyrA1AB | parC1aAB |
| H (20) | Canada, United States, South Africa, New Zealand, UAE | CTX-M-15 (20) | aac(6′)-lb-cr (19) | C | H30 | 20 | gyrA1AB | parC1aAB |
| I (10) | Canada, United States, New Zealand | CTX-M-15 (10) | aac(6′)-lb-cr (4) | C | H30 | 10 | gyrA1AB | parC1aAB |
| J (17) | Canada, United States, South Africa, UAE, New Zealand, the Netherlands | CTX-M-15 (12), CTX-M-14 (5) | aac(6′)-lb-cr (10) aac(6′)-lb-cr + qnrB (3) | C | H30 | 12 | gyrA1AB | parC1aAB |
| K (29) | Canada, United States, UAE, South Africa, New Zealand, India | CTX-M-15 (28), CTX-M-14 (1) | aac(6′)-lb-cr (23) | C | H30 | 28 | gyrA1AB | parC1aAB |
| L (38) | Canada, United States, UAE, South Africa, Brazil, the Netherlands, India | CTX-M-15 (36), CTX-M-3 (2) | aac(6′)-lb-cr (30) | A | H30 | 38 | gyrA1AB | parC1aAB |
| M (14) | Canada, India, South Africa, the Netherlands | CTX-M-15 (14) | aac(6′)-lb-cr (8) aac(6′)-lb-cr + qnrB (2) | A | H30 | 14 | gyrA1AB | parC1aAB |
| N (4) | Canada | CTX-M-15 (4) | aac(6′)-lb-cr (3) | C | H35 | 0 | gyrA1AB | parC1aAB |
| O (14) | Canada, France, the Netherlands, New Zealand | CTX-M-15 (4), CTX-M-3 (1), CTX-M-14 (9) | Neg | C | H41 | 0 | gyrA1AB, gyrA1A | parC3A, parC1b |
| NR (10) | Canada, Brazil, United States, South Africa, New Zealand | CTX-M-15 (6), CTX-M-14 (3), TEM-52 (1) | aac(6′)-lb-cr (2), aac(6′)-lb-cr + qnrB (1) | C, D | H30, H22 | 0 | gyrA1AB gyrA1A | parC1aAB, parC1b |
a
The isolates that belonged to pulsotypes A to O had >80% similar PFGE profiles among the isolates of each pulsotype. The remaining ESBL-producing isolates referred to as NR (not related) were not clonally related, i.e., they exhibited <60% similar PFGE profiles and did not show patterns similar to those from pulsotypes A to O.
b
PMQR, plasmid-mediated quinolone resistance.
c
Neg, negative.