TABLE 1.

Daptomycin concentrations in plasma (C_1HOUR and C_OP), in bones (C_THIGHBONE and C_SHINBONE), and in synovial fluid (C_SF)

Patient	Replacement	C1HOUR (μg/ml)	COP (μg/ml)	Time between C1HOUR and COP (h:min)	CTHIGHBONE (μg/g bone)	CSHINBONE (μg/g bone)	CSF (μg/ml)
1	Knee	71.3	43.0	04:00	1.4	2.0	23.3
2	Knee	110.3	69.9	04:00	2.0	2.2	25.0
3	Knee	67.8	43.4	05:25	1.6	4.4	15.6
4	Knee	72.6	42.5	05:03	4.5	4.5	22.4
5	Knee	100.3	56.4	06:20	1.7	2.4	18.5
6	Knee	39.4	21.6	06:42	2.5	2.5	13.1
7	Hip	76.2	40.4	05:15	4.2		35.0
8	Hip	87.6	43.4	07:49	4.8		24.1
9	Knee	70.5	44.8	09:30	4.2	8.1	27.0
10	Hip	90.3	39.9	09:19	5.9		30.8
11	Hip	55.0	24.7	08:56	3.0		14.2
12	Hip	54.6	28.2	10:53	5.7
13	Knee	71.3	41.0	04:55	3.1	1.6	15.8
14	Knee	76.4	45.6	05:11	3.7	2.9
15	Knee	55.3	29.8	09:17	2.2	2.9	15.9
16	Hip	25.4	13.4	05:25	2.2