TABLE 2.

Pharmacokinetics of thioridazine in mice^a

Test species	Drug doseb	Cmax (ng/ml)	Tmax (h)	t1/2 (h)	AUC0→∞ (ng · h/ml)
Mouse (serum)	25 mg/kg (SD)	79.2	9.0	3.4	931.5
	37.5 mg/kg (SD)	89.3	9.0		1,693.1
	50 mg/kg (SD)	100.9	9.0		1,306.1
	25 mg/kg(SS)	86.2	1	5.43	852
Mouse (lung)	25 mg/kg (SS)	3,326	1	2.37	26,112
Guinea pigc	5 mg/kg (SD)	404 ± 154.86	1.50 ± 0.71	3.19 ± 1.44	2,187.95 ± 9.98
Humand	25 mg (SD)	110.83 ± 51.07	1.77 ± 0.81	6.82 ± 1.67	554.86 ± 276.04
Humand	50 mg (SD)	197.13 ± 101.86	1.36 ± 0.39	8.24 ± 1.53	1,084.30 ± 582.75
Humand	100 mg (SD)	371.80 ± 137.10	1.48 ± 0.38	9.25 ± 1.91	2,639.30 ± 859.20

^aData are means ± standard deviations for a minimum of 3 animals.

^bSD, single dose; SS, steady state.

^cSee reference 27.

^dSee reference 34.