TABLE 2.
Arithmetic means (%CV) of the pharmacokinetic parameters of posaconazole after single-dose administration of posaconazole tablets (400 mg) alone or with concomitant medications to healthy volunteers
| Treatment | Pharmacokinetic parameters (arithmetic mean [%CV])a |
||||
|---|---|---|---|---|---|
| Cmax (ng/ml) | AUC0–inf (h · ng/ml) | AUC0–last (h · ng/ml) | Tmax (h)b | t1/2 (h) | |
| POS alone | 1,090 (43) | 42,406 (49) | 40,967 (47) | 4 (2–8) | 27.3 (37) |
| POS + antacid | 1,112 (36) | 42,468 (39) | 41,247 (39) | 4.8 (3–12) | 27.7 (29) |
| POS + ranitidine | 1,094 (37) | 39,287 (37) | 38,046 (35) | 4 (3–5) | 26.9 (35) |
| POS + esomeprazole | 1,104 (35) | 41,574 (43) | 40,083 (40) | 4.5 (3–24) | 28.0 (30) |
| POS + metoclopramide | 935 (44) | 38,513 (43) | 36,975 (40) | 4 (2–6) | 29.0 (38) |
a
AUC0–inf, area under the concentration-time curve from time zero to infinity; AUC0–last, area under the concentration-time curve from time zero to time of the last quantifiable sample; Cmax, maximum observed concentration of drug in serum; CV, coefficient of variation; POS, posaconazole; Tmax, time to Cmax; t1/2, apparent terminal half-life.
b
Median (minimum to maximum).