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Dose-dependent PFV PR-RT inhibition by HIV-1 RHIs. PFV PR-RT-associated RNase H (filled circles) and RDDP (open circles) activities were assayed at 37°C as described for 1 h (RNase H) and 30 min (RDDP), in the absence and in the presence of different concentrations of RDS1643 (A), VU6 (B), β-thujaplicinol (C), and NSC657589 (D). The results represent the average and standard deviation values of three independent experiments.
