TABLE 1.
Observed PI dispositions in plasma and PBMCs
| Parameter | Median (interquartile range) for concomitant PI |
||||
|---|---|---|---|---|---|
| ATV | DRV600a | DRV800b | LPV | TPV | |
| No. of samples | 40 | 22 | 4 | 21 | 16 |
| PI intra-PBMC concn (μM) | 2.51 (1.33–4.33) | 0.59 (0.40–1.09) | 0.743 (0.256–2.430) | 3.98 (3.18–6.73) | 6.78 (2.15–9.68) |
| PI plasma concn (μM) | 0.82 (0.47–1.38) | 6.35 (4.92–8.69) | 5.70 (3.35–16.75) | 11.74 (7.43–13.58) | 71.28 (43.33–96.19) |
| PI intra-PBMC/plasma ratio | 2.51 (1.63–5.06) | 0.09 (0.06–0.22) | 0.11 (0.06–0.24) | 0.51 (0.28–1.12) | 0.15 (0.13–0.18) |
a
DRV600, DRV-RTV 600 and 100 mg BID.
b
DRV800, DRV-RTV 800 and 100 mg QD.