FIG 4.
Simulated PTAs by sepsis (A), day after burn injury (B), and different levels of renal function (C) after a 30-min infusion of 4.5 g piperacillin-tazobactam q8h (4 g q8h as piperacillin) at steady state. Panel C contains all patient groups regardless of sepsis status or days after burn injury. Simulated PTAs by different infusion times (D) or daily doses (E) (as piperacillin) for CLCR values of ≥ 160 ml/min. The PK/pharmacodynamic (PD) target value for these PTAs is fT>MIC of at least 50%.