TABLE 2.
Population PK parameters of piperacillin in burn patients
| Parameter | Estimated value | % RSEa | Bootstrap median (95% CIb) |
|---|---|---|---|
| Structural model | |||
| TVCLc = θ1 × (CLCR/132) + (DAI × θ5) | |||
| θ1 | 16.6 liters/h | 5.96 | 16.2 (13.4–18.4) |
| θ5 | −0.0874 liters/h | 21.9 | −0.0862 (−0.122 to −0.0336) |
| TVV1d = θ2 + sepsis × θ6 | |||
| θ2 | 25.3 liters | 7.79 | 24.4 (21.0–29.6) |
| θ6 | 14.8 liters | 28.5 | 13.9 (6.07–24.2) |
| V2 | 16.1 liters | 52.9 | 15.4 (3.72–931) |
| Q | 0.636 liters/h | 22.5 | 0.730 (0.420–2.62) |
| Interindividual variability (CV%) | |||
| ωCL | 35.4% | 26.3 | 34.5 (23.7–45.0) |
| ωV1 | 42.4% | 31.3 | 35.5 (22.9–51.3) |
| ρCL-V1 | 0.434 | 0.589 (0.121–0.832) | |
| ωQ | 90.3% | 38.1 | 79.1 (0.316–122) |
| Residual error | |||
| σadditive | 0.359 mg/liter | 41.4 | 0.348 (0.000–0.590) |
| σproportional | 18.5% | 20.3 | 17.1 (10.3–25.0) |
a
RSE, relative standard error.
b
95% CI estimated by applying the final population PK model to 1,000 resampled data sets.
c
TVCL, typical value of clearance.
d
TVV1, typical value of central volume of distribution.