TABLE 1.
Pharmacokinetic parameters derived from total mean concentrations in female mice (n = 3 per time point) after single oral applications of 10 or 60 mg/kg pritelivir
| Parametera | Data for mice given pritelivir dose of: |
|
|---|---|---|
| 10 mg/kg | 60 mg/kg | |
| AUC0–48 (h·μg/ml) | 233 | 951 |
| AUC0–24 (h·μg/ml) | 219 | 852 |
| AUC0–∞ (h·μg/ml) | 233 | 956 |
| AUC0–∞/D (h·kg·μg/ml/mg) | 23.3 | 15.9 |
| AUC∞ex (%) | 0.188 | 0.535 |
| Cmax (μg/ml) | 17.7 | 68.7 |
| Cmax/D (kg·μg/ml/mg) | 1.77 | 1.14 |
| C24h (μg/ml) | 1.09 | 6.73 |
| C24h/D (kg·μg/ml/mg) | 0.109 | 0.112 |
| CL/F (ml/h/kg) | 42.8 | 62.7 |
| t1/2z (h) | 5.38 | 6.64 |
| Tmax (h) | 4.00 | 3.00 |
a
AUC0–48, area under the curve for 0 to 48 h; AUC0–24, area under the curve for 0 to 24 h; AUC0–∞, area under the curve for 0 h to infinity; D, dose; AUC∞ex, extrapolated proportion of AUC0–∞; Cmax, maximum plasma concentration; C24h, plasma concentration 24 h after dosing; CL/F, oral clearance; t1/2z, terminal half-life; Tmax, time to reach Cmax.