TABLE 1.

In vitro activities against C. albicans and cytoxicities of selected HDP mimetics

Compound	C. albicans GDH2346				Cytotoxicity (EC50 [μg/ml], EC50/MIC)
	IC50 (μg/ml)		MIC (μg/ml)
	Yeast cultures	Hyphal cultures	Without saliva	With saliva	NIH 3T3 cells	HepG2 cells	OKF6/TERT cells
1 (mPE)	4.88	11.04	4–8	32	52, 6.8	31, 3.9	68, 8.5
2 (519)	4.93	4.9	4–8	4–8	439, 55	>1,000, >125	>1,000, >125
3	4.24	0.71	4	4	311, 78	453, 113	466, 116
4	1.44	2.68	4	2	436, 109	885, 221	766, 192
5	1.09	1	2	4	108, 54	310, 155	371, 186
6	1.03	1.4	2	4	149, 75	288, 144	502, 251
7	2.2	NDa	2	16	461, 231	904, 452	ND, ND
8	2.08	2.22	2	16	523, 262	723, 362	718, 359

^aND, not determined.