TABLE 1.
Trypanocidal activity (EC50) of the studied arylimidamides against bloodstream trypomastigotes of T. cruzi (Y strain) and their selectivity index related to cardiomyocytes (EC50)
| Compound | EC50 (mean ±SD) (μM) in: |
SI (24 h)a | ||
|---|---|---|---|---|
| Trypomastigotes |
Cardiomyocytes (24 h) | |||
| 2 h | 24 h | |||
| 18SAB075 | 11 ± 1 | 0.3 ± 0 | >32 | >106 |
| 16DAP002 | 14 ± 3 | 3 ± 1 | >32 | >11 |
| 27SMB009 | >100 | 85 ± 21 | >32 | >0.4 |
| 23SMB054 | >100 | >100 | >32 | |
| 23SMB022 | >100 | >100 | >32 | |
| 23SMB026 | >100 | >100 | >32 | |
| 26SMB070 | >100 | >100 | >32 | |
| 16SAB079 | >100 | >100 | >32 | |
| Benznidazole | >100 | 13 ± 2b | 1,000 | 77 |
a
Treatment for 24 h at 37°C. Selectivity index (SI) = EC50 for cardiomyocytes/EC50 for parasites.
b
Value from da Silva et al. (16).