FIG 1.

Simultaneous PK model of plasma and ELF colistin concentrations after i.v. administration or intratracheal administration of nebulized colistin, where V_c is the volume of the central compartment, V_ELF is the fixed volume of the ELF compartment (30 μl/kg), and V_p is the volume of the peripheral compartment. CL_T corresponds to total plasma clearance, Q is the equilibrium distribution clearance between the central and peripheral compartments, and Q_ELF is the diffusion clearance between the central compartment and ELF. V_{max, in} is the maximum transfer rate from the ELF to the plasma compartment, k_m corresponds to the concentration at which the rate is half the maximum rate, and γ is the slope factor. F_aero is the systemic bioavailability after aerosol administration.