TABLE 3.
Resistance incidence of vancomycin-susceptible and -resistant E. faecalis and E. faecium strains against surotomycin, vancomycin, and rifampin
| Enterococcal strain | Antibiotic | Concn(s) tested (× MIC) | RIa |
|
|---|---|---|---|---|
| Sample A | Sample B | |||
| VSEfs | Surotomycin | 8, 16, 32 | <1.33E−09 | <2.34E−09 |
| Vancomycin | 8, 16, 32 | <1.33E−09 | <2.34E−09 | |
| Rifampin | 8, 16 | >1.3E−06 | >2.3E−07 | |
| VSEfm | Surotomycin | 8, 16, 32 | <2.9E−09 | <1.97E−09 |
| Vancomycin | 8, 16, 32 | <2.9E−09 | <1.97E−09 | |
| VREfs | Surotomycin | 8 | 3.2E−09 | <9.09E−10 |
| 16 | <1.6E−09 | 9.1E−10 | ||
| 32 | <1.6E−09 | <9.09E−10 | ||
| Rifampin | 8 | >8.0E−07 | >1.6E−07 | |
| 16 | 1.4E−08 | 7.8E−08 | ||
| VREfm | Surotomycin | 8, 16, 32 | <3.39E−09 | <4.04E−09 |
a
The average numbers of CFU/ml plated for vancomycin-susceptible and -resistant E. faecalis and E. faecium strains were as follows: 4.3E+08 to 7.5E+08 for VSEfs, 3.5E+08 to 5.1E+08 for VSEfm, 6.3E+08 to 1.1E+09 for VREfs, and 2.4E+08 to 3.0E+08 for VREfm.