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. 2010 Mar 2;3(5-6):377–385. doi: 10.1242/dmm.003434

Fig. 1.

Fig. 1.

APP processing and Aβ plaque formation. Amyloidogenic processing of APP occurs as a result of the β-secretase activity of BACE. This results in the production of the sAPPβ and the β-CTF. Intramembranous cleavage of the β-CTF by the γ-secretase enzymatic complex results in the production of Aβ which can subsequently aggregate to form plaques. Non-amyloidogenic processing is a result of APP cleavage by α-secretase which takes place within the Aβ sequence, precluding its formation, and is considered to be neuroprotective.