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. 2014 Apr 30;10(1):82–88. doi: 10.3892/mmr.2014.2201

Figure 4.

Figure 4

Effect of KNDC1 knockdown on signaling pathways. HUVECs were transfected with KNDC1-siRNA or NT-siRNA. Following incubation for 72 h, the expression levels of eNOS, VCAM-1, ICAM-1, p21, p16 and p-ERK, p38, JNK and p53 were examined by western blot analysis (n=3). Values are presented as the mean ± standard deviation. *P<0.05 vs NT-siRNA. KNDC1, kinase noncatalytic C-lobe domain containing 1; HUVECs, human umbilical vein endothelial cells; NT-siRNA, non-targeting control pool; p, phosphorylated; siRNA, small interfering RNA; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; eNOS, endothelial nitric oxide synthase; VCAM-1, vascular cell adhesion molecule 1; ICAM-1, intercellular adhesion molecule 1.