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. Author manuscript; available in PMC: 2015 Jul 1.
Published in final edited form as: Curr Pain Headache Rep. 2014 Jul;18(7):429. doi: 10.1007/s11916-014-0429-0

Figure 1. μ-Opioid Brain Profile of a Migraine Attack in vivo.

Figure 1

The ictal phase (lower row) – headache phase - shows a decrease in μ-opioid receptor availability (μOR BPND) in the pain-matrix regions. This result possibly represents an increase in endogenous μ-opioid release during the migraine attack, as a regulatory response to the ongoing severe headache. Key words: thalamus (Thal), nucleus accumbens (NAcc), and anterior cingular cortex (ACC). (DaSilva AF, Nascimento TD, Love TM, DosSantos MF, Martikainen IK, Cummiford CM et al. Impact of a Spontaneous Migraine Attack in the Endogenous μ-Opioid System In-Vivo. J Vis Exp. 2013;In Press)