Table 1.
Statistical summary of genetic susceptibility factors with systemic adverse event following smallpox vaccination
| GSF & | Allele | Gene | Odds ratio (confidential interval) | P-value | Study 1 or 2 |
|---|---|---|---|---|---|
| rs1801133 SNP |
T |
MTHFR |
2.3 (1.1–5.2) |
0.04 |
1 |
| rs1801133 SNP |
T |
MTHFR |
4.1 (1.4–11.4) |
0.01 |
2 |
| rs9282763 SNP |
G |
IRF1 |
3.2 (1.1–9.8) |
0.03 |
1 |
| rs9282763 SNP |
G |
IRF1 |
3.0 (1.1–8.3) |
0.03 |
2 |
| rs839 SNP |
A |
IRF1 |
3.2 (1.1–9.8) |
0.03 |
1 |
| rs839 SNP |
A |
IRF1 |
3.0 (1.1–8.3) |
0.03 |
2 |
| Haplotype 1* |
G,A |
IRF1 |
3.2 (1.0–10.2) |
0.03 |
1 |
| Haplotype 1* |
G,A |
IRF1 |
3.0 (1.0–9.0) |
0.03 |
2 |
| Haplotype 2# |
T,C,A |
IL4 |
2.4 (1.0–5.7) |
0.05 |
1 |
| Haplotype 2# | T,C,A | IL4 | 3.8 (1.0–14.4) | 0.06$ | 2 |
Notes:
&GSF stands for Genetic Susceptibility Factor.
*Haplotype 1 contains G allele of rs9282763, and A allele of rs839 in IRF1 gene.
#Haplotype 2 contains T allele of rs2070874, C allele of rs2243268, and A allele of rs2243290 in IL4 gene.
$In the second study, Haplotype 2 didn’t achieve the significant level of p value.
The data of this table is summarized and curated from Reif. et al.’s work on the genetic analysis of adverse event after smallpox vaccination [37].