Table 2:
IL-17A Gene Targets in Human Airway Smooth Muscle Cells from All Subjects
| P Value | Fold | Entrez ID | Name | Description | Location | Type | |
|---|---|---|---|---|---|---|---|
| 1 | 0.000 | 4.48 | 64,332 | NFKBIZ* | Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta | Nucleus | Transcription regulator |
| 2 | 0.000 | 1.98 | 80,149 | ZC3H12A* | Zinc finger CCCH-type containing 12A | Unknown | Other |
| 3 | 0.000 | 2.08 | 4,792 | NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha | Cytoplasm | Other |
| 4 | 0.001 | 1.40 | 5,971 | RELB | V-rel reticuloendotheliosis viral oncogene homolog B | Nucleus | Transcription regulator |
| 5 | 0.003 | 1.55 | 330 | BIRC3 | Baculoviral IAP repeat-containing 3 | Cytoplasm | Enzyme |
| 6 | 0.003 | 2.55 | 2,919 | CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | Extracellular space | Cytokine |
| 7 | 0.005 | 1.21 | 85,463 | ZC3H12C* | Zinc finger CCCH-type containing 12C | Unknown | Other |
| 8 | 0.005 | 1.72 | 7,128 | TNFAIP3* | TNF-α–induced protein 3 | Nucleus | Other |
| 9 | 0.006 | 1.55 | 1,326 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Cytoplasm | Kinase |
| 10 | 0.006 | 1.41 | 2,920 | CXCL2 | Chemokine (C-X-C motif) ligand 2 | Extracellular space | Cytokine |
| 11 | 0.006 | 1.25 | 54,897 | CASZ1 | Castor zinc finger 1 | Nucleus | Enzyme |
| 12 | 0.008 | 1.35 | 8,870 | IER3 | Immediate early response 3 | Cytoplasm | Other |
| 13 | 0.011 | 1.22 | 79,165 | LENG1 | Leukocyte receptor cluster member 1 | Unknown | Other |
| 14 | 0.012 | 1.27 | 6,648 | SOD2 | Superoxide dismutase 2, mitochondrial | Cytoplasm | Enzyme |
| 15 | 0.012 | 1.26 | 6,236 | RRAD | Ras-related associated with diabetes | Cytoplasm | Enzyme |
| 16 | 0.012 | 1.24 | 4,791 | NFKB2 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | Nucleus | Transcription regulator |
| 17 | 0.015 | 1.33 | 3,398 | ID2 | Inhibitor of DNA binding 2, dominant negative helix-loop-helix protein | Nucleus | Transcription regulator |
| 18 | 0.024 | 1.21 | 83,940 | TATDN1 | TatD DNase domain containing 1 | Unknown | Other |
| 19 | 0.029 | 1.24 | 874 | CBR3 | Carbonyl reductase 3 | Cytoplasm | Enzyme |
| 20 | 0.030 | 1.22 | 6,348 | CCL3 | Chemokine (C-C motif) ligand 3 | Extracellular space | Cytokine |
| 21 | 0.032 | 1.27 | 3,383 | ICAM1 | Intercellular adhesion molecule 1 | Plasma membrane | Transcription regulator |
| 22 | 0.035 | 1.22 | 14,6850 | PIK3R6 | Phosphoinositide-3-kinase, regulatory subunit 6 | Cytoplasm | Other |
| 23 | 0.039 | 1.20 | 4,616 | GADD45B | Growth arrest and DNA-damage–inducible, beta | Cytoplasm | Other |
| 24 | 0.046 | 1.22 | 8,747 | ADAM21 | ADAM metallopeptidase domain 21 | Plasma Membrane | Peptidase |
| 25 | 0.049 | 1.23 | 7,597 | ZBTB25 | Zinc finger and BTB domain containing 25 | Nucleus | Transcription regulator |
Definition of abbreviations: ADAM, A disintegrin and metalloproteinase; BTB, born to bind; TatD, twin arginine translocation D.
Up-regulated genes 2 hours after IL-17 stimulation compared with unstimulated controls. Gene list is sorted on probability values (P ≤ 005 and F ≥ 12) and excludes genes not categorized by the National Center for Biotechnology Information RefSeq accession format as a mature transcript product (prefix NM).
*
Genes validated by quantitative RT-PCR.