Table 3:
IL-17A Gene Targets from Airway Smooth Muscle Cells from Individuals with Mild Asthma
| P value | Fold | Entrez ID | Name | Description | Location | Type |
|---|---|---|---|---|---|---|
| 0.001 | 1.52 | 1326 | MAP3K8 | Mitogen-activated protein kinase kinase kinase 8 | Cytoplasm | Kinase |
| 0.003 | 1.22 | 26873 | OPLAH | 5-oxoprolinase (ATP-hydrolysing) | Unknown | Enzyme |
| 0.005 | 1.31 | 392376 | OR13C2 | Olfactory receptor, family 13, subfamily C, member 2 | Unknown | Other |
| 0.006 | 1.54 | 8870 | IER3 | Immediate early response 3 | Cytoplasm | Other |
| 0.007 | 1.20 | 55319 | C4ORF43 | Chromosome 4 open reading frame 43 | Unknown | Other |
| 0.007 | 1.24 | 337879 | KRTAP8-1 | Keratin-associated protein 8-1 | Unknown | Other |
| 0.008 | 1.78 | 80149 | *ZC3H12A | Zinc finger CCCH-type containing 12A | Unknown | Other |
| 0.008 | 1.25 | 85376 | RIMBP3 | RIMS binding protein 3 | Unknown | Other |
| 0.009 | 1.42 | 127069 | OR2T10 | Olfactory receptor, family 2, subfamily T, member 10 | Unknown | Other |
| 0.009 | 1.24 | 338328 | GPIHBP1 | Glycosylphosphatidylinositol anchored high density lipoprotein binding protein-1 | Unknown | Other |
| 0.009 | 1.20 | 343069 | HNRNPCL1 | Heterogeneous nuclear ribonucleoprotein C-like 1 | Nucleus | Other |
| 0.010 | 4.52 | 64332 | *NFKBIZ | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | Nucleus | Transcription regulator |
| 0.010 | 1.23 | 9232 | PTTG1 | Pituitary tumor-transforming 1 | Nucleus | Transcription regulator |
| 0.011 | 1.35 | 623 | *BDKRB1 | Bradykinin receptor B1 | Plasma Membrane | G-protein coupled receptor |
| 0.012 | 2.51 | 2919 | CXCL1 | Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) | Extracellular Space | Cytokine |
| 0.014 | 1.32 | 2162 | F13A1 | Coagulation factor XIII, A1 polypeptide | Extracellular Space | Enzyme |
| 0.015 | 1.34 | 3569 | *IL6 | Interleukin-6 (interferon, beta 2) | Extracellular Space | Cytokine |
| 0.016 | 1.26 | 4057 | LTF | Lactotransferrin | Extracellular Space | Peptidase |
| 0.017 | 1.40 | 3627 | CXCL10 | Chemokine (C-X-C motif) ligand 10 | Extracellular Space | Cytokine |
| 0.017 | 1.22 | 4033 | LRMP | Lymphoid-restricted membrane protein | Cytoplasm | Other |
| 0.018 | 1.33 | 7100 | TLR5 | Toll-like receptor 5 | Plasma Membrane | Transcription regulator |
| 0.019 | 1.96 | 4792 | *NFKBIA | Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | Cytoplasm | Other |
| 0.019 | 1.89 | 2920 | CXCL2 | Chemokine (C-X-C motif) ligand 2 | Extracellular Space | Cytokine |
| 0.020 | 1.40 | 390637 | LOC390637 | Chromosome 15 open reading frame 58 | Unknown | Other |
| 0.023 | 1.28 | 388531 | RGS9BP | Regulator of G protein signaling 9 binding protein | Unknown | Other |
Up-regulated genes 2 hours after IL-17 stimulation compared with unstimulated controls. Gene list is sorted on probability values (P ≤ 005 and F ≥ 12) and excludes genes not categorized by the National Center for Biotechnology Information RefSeq accession format as a mature transcript product (prefix NM); underlined genes are shared with the pooled group.
*
Genes validated by quantitative RT-PCR.